IndraLab

Statements

UCHL1 inhibits UCHL1. 4 / 9
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"UCHL1 plasma levels decrease after LDN-57444 treatment, suggesting the application of plasma UCHL1 as a treatment monitoring indicator.Increasing evidence shows that the nuclear pore complex regulates the nucleocytoplasmic transportation of key molecular factors to drive cancer progression.47 64 65 66 Inhibition of the nuclear pore complex induces cancer cell death.64 POM121 is highly expressed in multiple cancers and directly interacts with importin-β, a nuclear import machinery component, to regulate two oncogenic transcription factors, E2F1 and c-MYC, in advanced PC."
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"Notably, the EMT phenotype of Cd transformed cells can be suppressed by forced ectopic expression of UCHL1, suggesting UCHL1 as a crucial modulator in the maintenance of the proper differentiation status in lung epithelial cells."
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"Consistent with this view, our findings support that parkin mediated K63 linked polyubiquitination of UCH-L1 promotes the degradation of UCH-L1 by the autophagy-lysosome pathway."
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"However, there is near-complete loss of UCHL1 in the mossy fiber layer after 2h-HCA, where axon terminals from the depleted dentate granule neurons are located (XREF_FIG)."
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