IndraLab

Statements

UCHL1 inhibits UCHL1. 3 / 8
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"However, there is near-complete loss of UCHL1 in the mossy fiber layer after 2h-HCA, where axon terminals from the depleted dentate granule neurons are located (XREF_FIG)."
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"Consistent with this view, our findings support that parkin mediated K63 linked polyubiquitination of UCH-L1 promotes the degradation of UCH-L1 by the autophagy-lysosome pathway."
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"Notably, the EMT phenotype of Cd transformed cells can be suppressed by forced ectopic expression of UCHL1, suggesting UCHL1 as a crucial modulator in the maintenance of the proper differentiation status in lung epithelial cells."
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