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UCHL3 increases the amount of AHR. 4 / 4
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"Silencing UCHL3 led to a reduced level of AhR protein, and UCHL3 overexpression led to an elevated AhR protein level (Fig. 2C)."
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"According to Western blot analysis results, protein levels of UCHL3, AhR and PD-L1 were all reduced in response to sh-UCHL3 treatment, while additional LV-AhR restored the protein levels of AhR and PD-L1 but showed on obvious effects on the UCHL3 protein level; consistently, LV-UCHL3 led to up-regulated protein levels of UCHL3, AhR and PD-L1, among which only the up-regulation of AhR and PD-L1 was reversed in response to additional sh-AhR treatment (Fig. 2M)."
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"Furthermore, overexpression of UCHL3 decreased the ubiquitination of endogenous AhR in A549 and H1299 cells (Fig. 4h, i), while depletion of endogenous UCHL3 elevated the ubiquitination level of endogenous AhR in H358 cells (Fig. 4j)."
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"WT UCHL3 obviously increased AhR and c-Myc protein levels, whereas the mutants did not (Fig. 6a)."
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