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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

PRPF19 inhibits ATXN3. 1 / 1

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"Using in vitro mammalian cell and in vivo Drosophila models, we found that overexpression of Prpf19 and prp19 reduces the level of expanded ATXN3-polyQ protein, as well as ameliorating SCA3 cytotoxicities and neurodegeneration, while knockdown of Prpf19 and prp19 exerts an opposing effect."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...