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PRPF19 inhibits ATXN3. 1 / 1

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"Using in vitro mammalian cell and in vivo Drosophila models, we found that overexpression of Prpf19 and prp19 reduces the level of expanded ATXN3-polyQ protein, as well as ameliorating SCA3 cytotoxicities and neurodegeneration, while knockdown of Prpf19 and prp19 exerts an opposing effect."

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IndraLab

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PRPF19 inhibits ATXN3. 1 / 1

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