IndraLab

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USP19 activates NLRP3. 2 / 2

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"In addition, USP19 inhibited the proteasomal degradation of inflammasome independent NLRP3 by cleaving its polyubiquitin chains."

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"Moreover, USP19 could directly promote M2 polarization by suppressing the activation of NLRP3 inflammasome to interferon regulatory factor-4 (IRF-4) (89)."

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INDRA sources:

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IndraLab

Statements

USP19 activates NLRP3. 2 / 2

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