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(-)-epigallocatechin 3-gallate inhibits STAT1. 29 / 29
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"We next tested whether EGCG not only inhibits STAT1 but also enhances autophagy in primary cardiac myocytes."
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"This could be a mechanism by which EGCG inhibits STAT1 activation and related actions on cytokines and growth factors."
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"Although we do not exclude a possibility that the doses and timing used here might not be optimal for EGCG to inhibit DNMT1 and STAT1 (our hypothesis) or to mask immunostimulatory receptors (Kanamune et al.) and concede that refinement of EGCG treatment might result in GvHD prevention, our preliminary results do not corroborate or confirm those of Kanamune et al. and suggest that the effect of EGCG on GvHD is, at best, minimal."
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"EGCG also reduced STAT1 activity in cells transiently expressing the STAT1 luciferase plasmid (XREF_FIG)."
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"Treatment with 2S,3R-6-methoxycarbonylgallocatechin (MCGE), an epigallocatechin gallate derivative isolated from black tea (Anhua dark tea), effectively suppresses STAT1 activation and inflammatory cytokines, and activates Nrf2 pathway to protect cells from reactive oxygen species production in UVB exposed keratinocyte cells (HaCaT)."
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"EGCG also inhibits STAT-1 activation."
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"58 STAT1 is upregulated in certain drug resistant cancers and inhibition of STAT1 by EGCG in colorectal cancer cells could contribute to the antitumor actions of this drug."
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No evidence text available
24417609
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"EGCG remarkably inhibited the seawater aspiration induced increase of both STAT1 and p-STAT1 (XREF_FIG)."
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"In conclusion, although EGCG may be an effective inhibitor of both DNMT1 and STAT1, the treatment of EGCG after allo-HSCT does not result in prevention or reduction of GvHD in four different GvHD models, suggesting that EGCG treatment might not be an effective therapy against GvHD in the clinic."
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"We further demonstrated that EGCG inhibited Th1 and Th17 differentiation by downregulating their corresponding transcription factors (STAT1 and T-bet for Th1, and STAT3 and RORgammat for Th17)."
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"Thus, as a potential adjunct anti-inflammatory agent, EGCG can block STAT1 dependent events in gut epithelia and monocytes and prevent IFN-gamma-induced increased epithelial permeability."
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"Treatment with IFN-gamma activated phospho-STAT1 was markedly attenuated by EGCG."
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"EGCG also inhibited STAT1 regulated gene products, such as COX2 and TNF-alpha, which were increased by cisplatin (XREF_FIG)."
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"As already reported above, we demonstrated that EGCG inhibits STAT1 activation both in vitro and in pre-clinical studies [47,50,52,53,54]."
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"Epigallocatechin-3-gallate (EGCG), the major constituent of green tea, has recently been reported to inhibit STAT-1 activity in noncardiac cells."
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"EGCG inhibits STAT-1 to mediate protective effects of EGCG in myocardial I/R injury xref ."
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"We found that EGCG inhibited the activation and binding of STAT1 to the IRF-1 promoter in response to IFN-gamma."
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"Menegazzi and colleagues showed that interferon-gamma-induced STAT-1 activation in carcinoma derived cell lines of non gut origin was blocked by EGCG [XREF_BIBR]."
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"It was proved that EGCG inhibited STAT1 activation in many cell lines like HePG2 cells."
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"EGCG inhibits STAT-1 to mediate protective effects of EGCG in myocardial I/R injury XREF_BIBR."
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"This finding is consistent with the above result after inhibition of STAT1 by EGCG and confirms that STAT1 is important for doxorubicin induced HIF-1alpha upregulation."
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"In various cell lines, including mammary carcinoma cell lines, cervical carcinoma cell line and hepatocarcinoma cell line EGCG inhibited activation of STAT1 without affecting STAT3 [XREF_BIBR]."
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"For example, EGCG could suppress the JAK/STAT1 pathway, then suppress indoleamine 2,3-dioxygenase expression in IFN-γ-induced murine dendritic cells [93]."
28335502
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"To confirm the specificity of EGCG inhibition of STAT1, we transfected HEECs with STAT1 siRNA in monolayer HEECs."
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"In vitro and in vivo experiments on HIV Tat transgenic mice suggest that EGCG derived from green tea flavonoids helps impair the STAT1 pathway, thus attenuating the IFN-γmediated JAK/STAT1 pathway, and can potentially be used as adjunctive components to cART [96, 98] ."
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"EGCG pretreatment inhibited the increase of STAT1 and p-STAT1, whereas there was no difference of STAT1 and p-STAT1 between the control and EGCG group."
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"Previous studies showed that EGCG inhibited STAT1 activation."
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"Our previous studies showed that (-)-epigallocatechin-3-gallate (EGCG) inhibits signal transducer activator of transcription 1 (STAT1) activation."
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