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(-)-epigallocatechin 3-gallate inhibits STAT1. 36 / 37
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"EGCG inhibits STAT-1 to mediate protective effects of EGCG in myocardial I/R injury XREF_BIBR."
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"In various cell lines, including mammary carcinoma cell lines, cervical carcinoma cell line and hepatocarcinoma cell line EGCG inhibited activation of STAT1 without affecting STAT3 [XREF_BIBR]."
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"Moreover, EGCG suppresses the activity of interferon-gamma (IFNγ), JAK1, JAK2, and STAT1/STAT3."
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"Moreover, Townsend et al. recently demonstrated that Epigallocatechin-3-gallate (EGCG), the major constituent of green tea, reduced STAT1 activation and the expression of its pro-apoptotic target gene[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Thus, as a potential adjunct anti-inflammatory agent, EGCG can block STAT1 dependent events in gut epithelia and monocytes and prevent IFN-gamma-induced increased epithelial permeability."
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"In vitro and in vivo experiments on HIV Tat transgenic mice suggest that EGCG derived from green tea flavonoids helps impair the STAT1 pathway, thus attenuating the IFN-γmediated JAK/STAT1 pathway, and can potentially be used as adjunctive components to cART [96, 98] ."
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"Moreover, EGCG inhibited IFN-γ-induced STAT1 activation in HepG2 cells ( Fig. 1 D)."
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"To confirm the specificity of EGCG inhibition of STAT1, we transfected HEECs with STAT1 siRNA in monolayer HEECs."
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"Although we do not exclude a possibility that the doses and timing used here might not be optimal for EGCG to inhibit DNMT1 and STAT1 (our hypothesis) or to mask immunostimulatory receptors (Kanamune et al.) and concede that refinement of EGCG treatment might result in GvHD prevention, our preliminary results do not corroborate or confirm those of Kanamune et al. and suggest that the effect of EGCG on GvHD is, at best, minimal."
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"IFN-γ/STAT1 signaling is considered to play a pro-inflammatory role and EGCG inhibits STAT1 activation in many cell lines."
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"In remarkable contrast, EGCG pretreatment in BMDCs completely inhibited the binding of phospho-STAT1 to the IRF-1 promoter ( Fig. 2 B)."
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"EGCG pretreatment inhibited the increase of STAT1 and p-STAT1, whereas there was no difference of STAT1 and p-STAT1 between the control and EGCG group."
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"Our previous studies showed that (-)-epigallocatechin-3-gallate (EGCG) inhibits signal transducer activator of transcription 1 (STAT1) activation."
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"In vascular endothelial cells, EGCG suppressed STAT1 pathway and IFN-γ-induced upregulation of P2X4-receptor mRNA [134]."
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"EGCG remarkably inhibited the seawater aspiration induced increase of both STAT1 and p-STAT1 (XREF_FIG)."
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"To our surprise, EGCG suppressed the formation of STAT1 homodimers induced by IFN-γ ( Fig. 2 B)."
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"EGCG also inhibits STAT-1 activation."
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"It was proved that EGCG inhibited STAT1 activation in many cell lines like HePG2 cells."
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"This could be a mechanism by which EGCG inhibits STAT1 activation and related actions on cytokines and growth factors."
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"For example, EGCG could suppress the JAK/STAT1 pathway, then suppress indoleamine 2,3-dioxygenase expression in IFN-γ-induced murine dendritic cells [93]."
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"We next tested whether EGCG not only inhibits STAT1 but also enhances autophagy in primary cardiac myocytes."
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"In conclusion, although EGCG may be an effective inhibitor of both DNMT1 and STAT1, the treatment of EGCG after allo-HSCT does not result in prevention or reduction of GvHD in four different GvHD models, suggesting that EGCG treatment might not be an effective therapy against GvHD in the clinic."
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"EGCG also reduced STAT1 activity in cells transiently expressing the STAT1 luciferase plasmid (XREF_FIG)."
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"EGCG also inhibited STAT1 regulated gene products, such as COX2 and TNF-alpha, which were increased by cisplatin (XREF_FIG)."
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"Menegazzi and colleagues showed that interferon-gamma-induced STAT-1 activation in carcinoma derived cell lines of non gut origin was blocked by EGCG [XREF_BIBR]."
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"This finding is consistent with the above result after inhibition of STAT1 by EGCG and confirms that STAT1 is important for doxorubicin induced HIF-1alpha upregulation."
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"Prior treatment with EGCG effectively prevented IFN-γ-induced activation of JAK2 and its downstream signaling molecules, STAT1 and STAT3, in human melanocytes."
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"Epigallocatechin-3-gallate (EGCG), the major constituent of green tea, has recently been reported to inhibit STAT-1 activity in noncardiac cells."
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"58 STAT1 is upregulated in certain drug resistant cancers and inhibition of STAT1 by EGCG in colorectal cancer cells could contribute to the antitumor actions of this drug."
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"EGCG inhibits STAT-1 to mediate protective effects of EGCG in myocardial I/R injury xref ."
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"Previous studies showed that EGCG inhibited STAT1 activation."
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"However, this is not a non-specific effect of the polyphenol since IL-4-induced STAT6 in gut-derived epithelial cells was not affected by EGCG co-treatment, whereas IFNγ-induced STAT1 mobilization in [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"EGCG, directly or through suppressing STAT1 activation, reduces high mobility group box (HMGB)1, a redox-sensitive pro-inflammatory nuclear protein mediating sepsis [272,273]."
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"Treatment with 2S,3R-6-methoxycarbonylgallocatechin (MCGE), an epigallocatechin gallate derivative isolated from black tea (Anhua dark tea), effectively suppresses STAT1 activation and inflammatory cytokines, and activates Nrf2 pathway to protect cells from reactive oxygen species production in UVB exposed keratinocyte cells (HaCaT)."
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"Since EGCG is considered only a weak anti-oxidant [34] , these data suggest that the EGCG inhibition of IL-2 production from activated immune cells is unlikely to be due to any anti-oxidant effects of[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"As already reported above, we demonstrated that EGCG inhibits STAT1 activation both in vitro and in pre-clinical studies [47,50,52,53,54]."
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