IndraLab

Statements

USP21 is phosphorylated on S538. 10 / 10
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rlimsp
"Taken together, our data indicate that USP21 at Ser538 is phosphorylated by HSV-1 infection."
28254948
rlimsp
"We next examined whether HSV-1 infection could induce the phosphorylation of USP21 at Ser538."
28254948
rlimsp
"HSV-1 infection recruited USP21 to STING at late stage by p38-mediated phosphorylation of USP21 at Ser538."
28254948
rlimsp
"Our data showed that infection with HSV-1 virus for 6 h significantly induced the phosphorylation of USP21 at Ser538, which was completely blocked by treatment with p38 inhibitor SB202190 in Flag-USP21 stably expressing HeLa cells (Fig. 9 E)."
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rlimsp
"We next examined whether Ser538 can be phosphorylated upon virus infection. To this end, we generated a rabbit polyclonal antibody that specifically recognized the phosphorylated USP21 at Ser538 (p-S538 antibody)."
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rlimsp
"DNA virus–induced phosphorylation of USP21 at Ser538."
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rlimsp
"Interestingly, we found that Ser538-phosphorylated USP21 is mainly localized at perinuclear microsome, which exhibits a similar localization with the activated STING."
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rlimsp
"Our data from mass spectrometry showed that HSV-1 infection significantly induced the phosphorylation of USP21 at multiple sites, including Ser93, Ser335, and Ser538 (Table S2 and Fig. 7 A)."
28254948
rlimsp
"In the late stage of virus infections, p38 MAPK is activated and subsequently induces the phosphorylation of USP21 at Ser538."
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rlimsp
"HSV infection can recruit USP21 to STING through p38-mediated phosphorylation of USP21 at Ser538."
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