IndraLab

Statements

USP15 inhibits mutated PRKN. 4 / 4
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"USP15 knockdown rescues the mitophagy defect of PARK2 mutant PD patient fibroblasts As demonstrated above in HeLa cells ( Fig. 2A) , USP15 knockdown does not enhance mitophagy in the complete absence of Parkin."
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": Knockdown of USP15 rescues the mitophagy defect of PARK2 mutant PD patient fibroblasts."
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"These data were also confirmed in vivo in Drosophila, where silencing of Usp15 homolog rescued parkin mutant phenotype, thus showing a genetic interaction between the two genes [XREF_BIBR]."
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"USP15 knockdown rescues the mitophagy defect of PARK2 mutant PD patient fibroblasts."
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