IndraLab

Statements

USP15 inhibits mutated PRKN. 3 / 3
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"USP15 knockdown rescues the mitophagy defect of PARK2 mutant PD patient fibroblasts."
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"These data were also confirmed in vivo in Drosophila, where silencing of Usp15 homolog rescued parkin mutant phenotype, thus showing a genetic interaction between the two genes [XREF_BIBR]."
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"Strikingly, knockdown of USP15 or USP30 causes enhanced degradation of depolarized mitochondria in cells expressing wild-type Parkin, and furthermore rescues mitophagy defects in cells expressing path[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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