IndraLab

Statements

VCPIP1 increases the amount of X. 5 / 5
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"VCPIP1 and its C-terminal amino acids 863 to 1221 upregulated the HBx protein expression, with or without HBV infection."
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"Regarding the DUB nature of VCPIP1 in the OTU subfamily, we presumed that VCPIP1 would increase the HBx protein expression."
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"To verify the VCPIP1-induced increase in the HBx protein levels, we used cycloheximide (CHX) to block protein synthesis to determine whether VCPIP1 altered HBx stability."
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"Conversely, knockdown of endogenous VCPIP1 expression in these models resulted in inhibition of HBV transcription and replication, along with moderately decreased production of secreted antigens, and reduced HBx protein levels (Fig. 2B)."
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"Clearly, upregulation of HBx protein level by VCPIP1-mediated stabilizing is also effective in these models of HBV replication and correlated with upregulated HBV gene expression and genome replication."
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