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USP2 activates Obesity. 2 / 2
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"Taken together, these results suggest that USP2 modulates thermogenic activation in brown adipocytes in a cell-autonomous manner.3.6 BAT-specific overexpression of USP2 promotes thermogenesis and improves HFD-induced obesity."

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"Conversely, overexpression of Usp2 in BAT conferred protection against high-fat diet-induced obesity and associated metabolic disorders."