IndraLab

"During CIRI, macrophages are recruited to and infiltrate the ischemic brain within hours. xref ICAM-1 and P-selectin are overexpressed on the luminal side of stressed vascular endothelial cells, xref and these molecules can interact with the CD44 and CD11b ligands on leukocytes recruited from the peripheral blood to promote infiltration into the lesion, whereas the recruitment is not affected by the degree of opening of the BBB. xref , xref Therefore, Jiang et al developed a macrophage‐disguised honeycomb manganese dioxide (MnO 2 ) nanosphere loaded with fingolimod (Ma@(MnO 2 +FTY)). xref The macrophage enabled Ma@(MnO 2 +FTY) to have inflammation-directed chemotaxis and promoted the recruitment of CD11b and CD44 to the lesion via a volume-dependent caveolin- mediated endocytic pathway into the cells, thus crossing the BBB and accurately delivering drugs to the ischemic penumbra."

"Although TANs do not seem to be implicated in the phagocytosis mechanism of rituximab activity [XREF_BIBR], in vitro and in vivo studies, have demonstrated that TANs may compromise the cytotoxic effect of common chemotherapeutic agents used through CD11b and ICAM -1 interaction with CD44 of malignant B cells and inhibit FL B cell apoptosis."

"Fig. 6 E shows that CD44 expression is closely associated with CD11b expression in leukemia cells treated with cyclopamine (correlation coefficient r = 0.76)."