IndraLab

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UCHL5 activates DNA Breaks, Double-Stranded. 2 / 2
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"In addition to identifying many DUBs with DDR roles, this work also lead to establish that one, UCHL5 promotes DSB end resection and HR through regulating the stability of the NFRKB protein that is a subunit of chromatin remodeling complex INO80."
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"UCHL5 (Ubiquitin carboxyl-terminal hydrolase isozyme L5) positively regulates DSB end resection and HR repair by deubiquitinating and stabilizing NFRKB protein (nuclear factor related to kappaB bindin[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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