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Cisplatin inhibits RELA. 6 / 6
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"Moreover, mutation of RelA at T505 abolished cisplatin mediated repression of the RelA TAD in luciferase reporter assays."
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"GA co-operates with cisplatin to increase the sensitivity of NSCLC cells to cisplatin by inhibiting NF-κB (p65 and p50), MAPK/ERK, MAPK/JNK, and promotes apoptosis in A549 and NCI-H460 cells [23]."
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"Our study also found that the level of IκBα were decreased and NF-κB p65 were increased in the nucleus of renal tubular cells after cisplatin induction, large doses of paricalcitol could inhibit the n[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"IHC studies showed reduced p65 staining in tumors of animals treated with 19 and cisplatin individually and the combination (XREF_FIG)."
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"As observed in the mRNA data, treatment of CDDP-exposed rats with DMFM considerably reversed the induction of STAT3, COX-2, TNF-α, NF-κB p65, and IL-1 proteins (Fig. 6)."
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"As shown in XREF_FIG, cisplatin induced p65 nuclear translocation was significantly reduced by betaL coadministration."
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