IndraLab

Statements

KCNH2 activates AKT. 12 / 12
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"The beta 1 / hERG1 complex modulates the PI3K-Akt pathway."
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"HERG1 recruits and activates PI3K and Akt."
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"18, 19 It has been known that Kcnh2 could modulate AKT signalling by interacting with integrin beta1."
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"Importantly, AKT could be also activated by Kcnh2 through interacting with integrin beta1 and FAK 41, 42 or enhancing the phosphorylation of AKT independently."
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"Importantly , AKT could be also activated by Kcnh2 through interacting with integrin beta1 / FAK 41 , 42 or enhancing the phosphorylation of AKT independently ."
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"18 , 19 It has been known that Kcnh2 could modulate AKT signalling by interacting with integrin beta1 ."
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"Importantly, AKT could be also activated by Kcnh2 through interacting with integrin β1/FAK xref , xref or enhancing the phosphorylation of AKT independently. xref Integrin β1/FAK contributes to promote vascular leakage in endotoxaemia. xref When here induced a defect of Kcnh2 by genetic manipulation, the activity of both FAK and AKT was obviously impaired, which further aggravated the apoptosis due to LPS challenge."
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"HERG1 promotes esophageal squamous cell carcinoma growth and metastasis through TXNDC5 by activating the PI3K and AKT pathway."
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"However, the situation was improved as long as activator bpV (HOpic) of AKT was applied, suggesting that Kcnh2 might mediate FAK and AKT signalling axis to modulate cardiomyocyte apoptosis during SICD."
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"These data indicate that Cla exerts its effect on CRC cell autophagy, by modulating hERG1.We previously showed that hERG1 channels stimulate the PI3K/Akt pathway by forming a macromolecular complex with the p85 subunit of PI3K, in human CRC cells ."
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"23 These evidences strongly suggest that Kcnh2 may mediate AKT and FOXO3A pathways to modulate the sepsis induced pathological process in heart."
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"Thence, Kcnh2 can modulate AKT activity to affect the expression of FOXO3A in SICD."
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