IndraLab

Statements

USP8 deubiquitinates CFLAR. 3 / 3
1 | 2
ubibrowser
"USP8 directly deubiquitylates and stabilizes FLIPL"
27321185
reach
"USP8 and USP9X deubiquitinate ITCH to induce ubiquitination and degradation of the anti-apoptotic protein c-FLIP, leading to apoptosis in glioblastoma [XREF_BIBR], or to anoikis in pancreatic ductal adenocarcinoma [XREF_BIBR]."
27203743
reach
"However, Jeong et al. [98] showed that USP8 directly interacts with the caspase-like domain in c-FLIP to induce deubiquitination and stabilization of cFLIP , but not cFLIP ."
31845722