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USP8 deubiquitinates CFLAR. 3 / 4
1 | 3
reach
"Recently, Jeong et al. demonstrated that USP8 directly interacted with the caspase-like domain in c-FLIP(L) and induced deubiquitination and stabilization of c-FLIP(L), but not c-FLIP(S)."
30638181
reach
"However, Jeong et al. [98] showed that USP8 directly interacts with the caspase-like domain in c-FLIP to induce deubiquitination and stabilization of cFLIP , but not cFLIP ."
31845722
reach
"USP8 and USP9X deubiquitinate ITCH to induce ubiquitination and degradation of the anti-apoptotic protein c-FLIP, leading to apoptosis in glioblastoma [XREF_BIBR], or to anoikis in pancreatic ductal adenocarcinoma [XREF_BIBR]."
27203743