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USP8 deubiquitinates CFLAR. 3 / 3

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"USP8 directly deubiquitylates and stabilizes FLIPL"

27321185

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"USP8 and USP9X deubiquitinate ITCH to induce ubiquitination and degradation of the anti-apoptotic protein c-FLIP, leading to apoptosis in glioblastoma [XREF_BIBR], or to anoikis in pancreatic ductal adenocarcinoma [XREF_BIBR]."

27203743

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reach

"However, Jeong et al. [98] showed that USP8 directly interacts with the caspase-like domain in c-FLIP to induce deubiquitination and stabilization of cFLIP , but not cFLIP ."

31845722

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USP8 deubiquitinates CFLAR. 3 / 3

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