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BAP1 inhibits ferroptosis. 9 / 9
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"Moreover, BAP1 partially prevents the progression of tumors via SLC7A11 as well as ferroptosis, and cancer-related BAP1 mutants end up losing their capacities to suppress SLC7A11 and to stimulate ferroptosis [25]."
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"Tumor suppressor BAP1 (BRCA1-associated protein 1) promotes ferroptosis and inhibits tumor development via a similar mechanism [92]."
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"Zhang et al. showed that BAP1 inhibits tumor progression by promoting cellular ferroptosis (15)."
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"BAP1 inhibits tumor development, in part, via SLC7A11 and ferroptosis [48]."
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"Furthermore, the tumor suppressor BRCA1-associated protein 1 suppresses SLC7A11 transcription by decreasing H2Aub, leading to elevated lipid peroxidation and thus, increased ferroptosis (49)."
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"In addition, Zhang et al. discovered that another tumor suppressor BAP1 promoted ferroptosis and inhibited the growth of cancer cells by inhibiting SLC7A11 (49)."
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"Also, BAP1 reversed the effects of Exos oe-GATA-4 on H/R-induced cardiomyocytes' ferroptosis by downregulating SLC7A11."
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"It has been reported that the inactivation of BAP1 upregulates SLC7A11 and suppresses ferroptosis, resulting in tumor development."
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"Several tumor-suppressors, such as p53 [69] , BAP1 [70] , and KEAP1 [71] , promote ferroptosis through inactivating SLC7A11, while some oncogenic signaling pathways such as PI3K-mTORC1 pathway have be[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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