IndraLab

Statements

S100A4 binds USP29. 6 / 6
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"To investigate the involvement of USP29-FSP1 signaling in GC chemoresistance, we initially assessed the protein expression levels of USP29 and FSP1 in various cancer cell lines."
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"After elucidating the function of the USP29-FSP1 axis in GC chemoresistance, we sought to identify the specific E3 ubiquitin ligase responsible for this process."
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"USP29 binds and stabilizes FSP1."
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"To further confirm the interaction between USP29 and FSP1, endogenous co-immunoprecipitation (Co-IP) assays were conducted, demonstrating that reciprocal immunoprecipitation of endogenous USP29 (or FSP1) effectively precipitated FSP1 (or USP29) (Fig.  xref )."
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"Notably, the enzymatic domain (UCH domain) of USP29 was identified as crucial for mediating the USP29-FSP1 interaction (Fig.  xref )."
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"USP29 directly interacts with FSP1, reducing its ubiquitination levels through its DUB activity, ultimately leading to the stabilization of FSP1."
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