IndraLab

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USP9X activates cell growth. 9 / 10
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"Collectively, our findings suggest that the deubiquitinase USP9X counteracts proteasomal degradation of EWS-FLI1 and thereby stabilizes EWS-FLI1 protein, and that inhibition of USP9X with a small mole[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Though we observe reduction of Ewing sarcoma cell growth after USP9X knockdown that coincides with a reduction in EWS-FL1 protein levels, it is possible that USP9X knockdown impairs cell growth in an [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"18 , 19 , 20 Conversely, deubiquitinase USP10 and USP9X stabilize YAP and promote cell growth and survival in HCC and breast cancer."
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"Although USP9X may function as a tumor-suppressor during the establishment of PDAC, data presented here argue that USP9X promotes cell growth in advanced PDAC cells when PDAC is typically diagnosed."
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"We investigated the role of USP9X in B-ALL and found that USP9X knockdown significantly reduced leukemic cell growth and increased spontaneous apoptosis, thereby improving survival in immunodeficient mice."
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"USP9X overexpression increased MCF-7 and MDA-MB-231 cell growth."
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"The colony formation assay showed that USP9X overexpression significantly increased MCF-7 and MDA-MB-231 cell growth compared with that of the empty vector cells (both, P<0.05) (Figure 3A, 3B)."
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"USP9X gene knockout significantly inhibited MCF-7 and MDA-MB-231 cell growth compared with that of cells transfected with negative CRISPR/Cas9 vector (both, P<0.05) (Figure 3A, 3B)."
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"The results indicate that USP9X overexpression can increase breast cancer cell growth, whereas USP9X gene knockout can decrease breast cancer cell growth."
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