IndraLab

Statements

Palmatine inhibits NLRP3. 3 / 3
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"Palmatine attenuated dextran sulfate sodium (DSS)-induced colitis via promoting mitophagy mediated NLRP3 inflammasome inactivation."
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"Moreover, palmatine suppressed NLRP3 inflammasomes activation, but enhanced the expression of the mitophagy related proteins involving LC3, PINK1 and Parkin in colonic tissue of DSS mice."
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"These effects was consistent with the in vitro data revealing that palmatine inhibited the activation of NLRP3 inflammasomes, while promoted the expression and mitochondrial recruitment of PINK1 and Parkin in THP-1 cell differentiated macrophages."
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