IndraLab

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JNK-IN-8 inhibits JUN. 2 / 2

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"Our data show that downregulation of c-Jun by JNK-IN-8 or shRNA knockdown increased the number of human multipotent progenitors and engraftable HSCs ."

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"JNK-IN-8 potently inhibits JNK1, 2 and 3 enzymatic activity with IC 50 s of 4.7 nM, 18.7 nM and 1.0 nM respectively and inhibits a c-Jun, a direct phosphorylation substrate of JNK, with an EC 50 of 486 nM in Hela cell."

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IndraLab

Statements

JNK-IN-8 inhibits JUN. 2 / 2

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