IndraLab

Statements

OPTN inhibits CYLD. 4 / 4
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"By recruiting CYLD, a crucial de-ubiquitin enzyme, OPTN could prevent the activation of TBK1 during RNA virus infection [ 14 ]."
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"In conclusion, our observations strongly suggest that optineurin mediates targeting of CYLD to its substrate (i.e ubiquitinated RIP) which facilitates its deubiquitination."
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"Optineurin also suppresses TNFR-mediated NF-κB signaling and TLR-mediated NF-κB signaling through interaction with the deubiquitinating enzyme, cylindromatosis (CYLD), and IL-1 receptor-associated kin[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Of note, optineurin, a gene in one of the other Paget 's susceptibility loci can also attenuate TNF-alpha signaling by recruiting CYLD to RIP1."
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