IndraLab

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BAP1 activates immune response. 4 / 4
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"However, beyond this experimental model, it is important to consider that BAP1 activities in other cell types may also contribute to the regulation of antibody mediated immunity in vivo."
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"These results indicate that BAP1 inactivation in MPM correlates with an increase in DCs and inflammatory macrophages and a decrease in immunosuppressive MDSCs, further supporting the notion that BAP1 deficiency promotes the immune response in MPM."
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"Here, our molecular profiling data revealed that BAP1-deficient MPM is enriched for immune-related pathways (e.g., IFN-α/γ response) and strongly correlates with the gene signature of DCs, a professional antigen-presenting cell type that induces the activation and differentiation of naive T lymphocytes,35 suggesting that BAP1 contributes to antitumor immunity in MPM beyond its function intrinsic to cancer cells.First, we observed that BAP1-deficient MPM exhibited increased expression of several inhibitory immune checkpoints, such as PD-L1, PD-1, and LAG3."
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"B-cell intrinsic regulation of antibody mediated immunity by histone H2A deubiquitinase BAP1."
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