IndraLab

Statements

Mutated USP12 activates MAP1LC3. 2 / 2
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"Moreover, there has no difference in the efficiency of USP12 and non-catalytic mutant of USP12 in stimulating the clearance of LC3, which is an autophagy protein that incorporates into autophagosomes, and selectivity degraded via autophagy."
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"Since a non catalytic mutant of Usp12, Usp12-C48S, stimulated LC3 clearance as efficiently as Usp12, we additionally conclude that this function of Usp12 is independent of its deubiquitinating activity."
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