IndraLab

Statements


BAP1 inhibits BARD1. 2 / 2
| 2

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"BAP1, a ubiquitin carboxy-terminal hydrolase, interacts with the RING finger domain of BARD1 to inhibit the E3 ligase activity of BRCA1/BARD1, protecting BRCA1 from proteasome-mediated degradation (37, 38)."

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"BAP1 acts as a tumor suppressor and inhibits E3 ligase activity in BRCA1/BARD1."