IndraLab

Statements

ANXA6 binds LRP1 and THBS1. 10 / 10
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"Specific membrane proteins such as CD151 [26, 27] and Netrin-1 [28], along with the ANXA6/LRP1/TSP1 complex [8], further enhance the invasiveness and migration capabilities of pancreatic cancer cells by participating in cell–cell interactions and signaling transduction."
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"Increased PDA aggressiveness was dependent on tumor cell mediated uptake of CAF derived ANXA6+ EVs carrying the ANXA6, LRP1, and TSP1 complex."
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"Leca et al. demonstrated that EVs derived from cancer-associated fibroblasts (CAFs) undergoing non-physiologic culture conditions were enriched in ANXA6 and stimulated tumor growth and aggressiveness probably by activating the ANXA6/LRP1/TSP1 complex [42]."
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"Interestingly, increased PDAC aggressiveness was associated with the tumor cell-mediated uptake of CAF-derived ANXA6+ EVs carrying the ANXA6/LRP1/TSP1 complex, whereas the depletion of ANXA6 in CAFs impaired the complex formation and subsequently the occurrence of metastasis [42]."
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"Increased PDAC aggressiveness was dependent on the tumor cell-mediated uptake of CAF-derived ANXA6-positive EVs carrying the ANXA6/LRP1/THBS1 complex."
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"Leca et al. reported that increased PC aggressiveness was dependent on tumor cell-mediated uptake of CAF-derived ANXA6 + EVs carrying the ANXA6/LRP1/TSP1 complex [35] ."
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"The formation of the ANXA6/LRP1/TSP1 complex is limited to CAFs, so the enhanced aggressiveness of PDA is mediated by the uptake of the CAF-derived EV-carrying complex by tumor cells [70]."
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"Interestingly, formation of the ANXA6/LRP1/TSP1 complex in vitro was only possible when CAFs were cultured under conditions that mimicked the pathophysiological environment of CAFs in vivo (i.e. macro[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Nevertheless, further studies are required to validate whether the ANXA6, LRP1, and TSP1 complex may enter exosomes to support the aggressiveness of PaCa."
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"Formation of the ANXA6, LRP1, and TSP1 complex was restricted to cancer associated fibroblasts (CAFs) and required physiopathologic culture conditions that improved tumor cell survival and migration."
27701147