IndraLab

Statements

Sulfasalazine inhibits CHUK. 3 / 3
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"Sulfasalazine (SSZ), an anti-inflammatory and immunosuppressive agent, inhibits IKKalpha and IKKbeta thereby blocking NFkB activation."
19796605
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"Sulfasalazine, a disease modifying anti-rheumatic drug (DMARD) launched for RA and other autoimmune disorders, was also reported to directly inhibit IKKalpha and IKKbeta by antagonizing ATP binding [XREF_BIBR]."
32708302
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"Sulfasalazine inhibited tumor necrosis factor alpha induced activation of endogenous IKK in Jurkat T cells and SW620 colon cells, as well as the catalytic activity of purified IKK-alpha and IKK-beta in vitro."
11054378