IndraLab

Statements

USP7 increases the amount of CCDC6. 7 / 7
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"The targeting of USP7 to reduce CCDC6 levels appears to be useful for the establishment of new therapeutic approaches in cancer treatment [XREF_BIBR - XREF_BIBR], since it could also affect the stability and turnover of the TKs fused to CCDC6."
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"The CCDC6 levels are modulated by the deubiquitinase USP7."
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"Pharmacological inhibition of USP7 downregulates the expression of CCDC6 involved in homologous recombination and results in DNA repair defects that increase the sensitivity of PARP inhibitors."
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"The CCDC6 levels are modulated by deubiquitinase ubiquitin specific protease 7 (USP7) (96)."
33968782
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"It has been reported that USP7 modulated the expression levels of CCDC6 in bladder cancer."
37215134
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"Here we show that the knockdown of USP7 reduces the levels of CCDC6 in HCT116 cells and increases their sensitivity to olaparib."
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"USP7 has been reported to modulate CCDC6 levels in bladder cancer and lung neuroendocrine cancers (129)."
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