IndraLab

Statements

ADCY9 binds AKAP9 and KCNQ1. 3 / 3
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sparser
"In cardiomyocytes, a pool of AC9 complexes with AKAP9 , PKA and the potassium channel KCNQ1 to favor cardiomyocyte repolarization after sympathetic stimulation (see xref ) [ xref , xref , xref ]."
33923648
sparser
"Importantly, formation of a KCNQ1–yotiao–AC9 complex sensitized KCNQ1 to β-adrenergic receptor stimulation, allowing the channel to respond to significantly lower concentrations of agonist ( xref )."
24378903
sparser
"The interaction of AC9 with Yotiao and KCNQ1 was shown by immunoprecipitation of the complex from cells co-expressing all three proteins, a transgenic mouse line with cardiac expression of KCNQ1–KCNE1, and from guinea pig hearts, which endogenously express the complex."
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