IndraLab

Statements

OTUD3 inhibits ERN1. 6 / 6
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"These results showed that OTUD3 knockdown-induced ER stress activated the IRE1α pathway."
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"OTUD3 knockdown increased the activation of IRE1α and the expression of XBP1s."
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"To explore the underlying mechanism by which OTUD3 knockdown activated the IRE1α pathway, we performed co-immunoprecipitation (Co-IP) to detect protein interactions."
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"Downregulation of OTUD3 reduced the binding ability of Fortilin to IRE1α, thereby activating the IRE1α pathway and inducing ER stress and neuronal apoptosis."
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"Taken together, we revealed that OTUD3 knockout-induced injury of dopaminergic neurons might be caused by activating IRE1alpha signaling in ER stress."
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"OTUD3 knockdown resulted in a decrease in the interaction ability of IRE1alpha with Fortilin and finally enhanced the activity of IRE1alpha ."
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