IndraLab

Statements

P5091 activates Multiple Myeloma. 8 / 8
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"The first USP7 inhibitor, P5091, was previously shown to inhibit multiple myeloma proliferation [31]."
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"P5091 was found to induce apoptosis in various MM cell lines as well as ex vivo cells, including those resistant to previous treatments [XREF_BIBR]."
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"Datas indicated that the USP7 inhibitor P5091 was overcoming bortezomib resistance in multiple myelomas by destabilizing NEK2 [30]."
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"Since our in vitro data showed that P5091 triggers apoptosis in p53-null ARP-1 MM cells, we evaluated whether P5091 similarly affects the growth of ARP-1 cells in vivo."
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"P5091 induces apoptosis of multiple myeloma cells that are resistant to bortezomib, a 20S proteasome inhibitor."
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"P5091 triggers apoptosis in MM cells even in the presence of the MM-host BM microenvironment."
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"These data suggest that P5091 not only directly targets MM cells, but also overcomes the cytoprotective effects of the MM-host BM microenvironment."
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"P5091 suppressed in vivo tumor growth [XREF_BIBR], caused apoptosis of Multiple Myeloma (MM) cells, and prolonged survival in xenograft models [XREF_BIBR]."
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