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Hydroxychloroquine inhibits NLRP3. 19 / 19
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"To further confirm whether HCQ suppresses NLRP3 inflammasome activation through reduction of CTSB and CTSL activity, we compared the effects of HCQ and Ca074Me on H/R induced HK-2 cell injury and NLRP3 inflammasome activation."
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"Also, hydroxychloroquine significantly reduces macrophage and neutrophil infiltration, the production of inflammatory cytokines, and the activation of NLRP3 inflammasome."
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"There is evidence that hydroxychloroquine may reduce the activity of NLRP3 in inflammatory cells."
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"In vitro studies demonstrated that HCQ attenuated activation of the NLRP3 inflammasome and blocked LMP."
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"XREF_FIG), and mRNA levels of IL-1beta, IL-6, TNF-alpha, and MCP-1 in HCQ group and HCQ+C a074Me group also showed no statistical significance, which confirmed that HCQ suppresses NLRP3 inflammasome through downregulation of CTSB and CTSL activity."
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"These data suggested that HCQ blocks NLRP3 inflammasome activation by reducing CTSB and CTSL activity."
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"Other studies found that CQ and HCQ inhibited lysosomal activity, suppressed the activation of NLRP3 inflammasomes, and modulated immune-related factors, such as toll-like receptors (TLRs) [28–32] ."
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"Tang et al. found Hydroxychloroquine (HCQ) could block the priming and activation of NLRP3 inflammasome in renal IRI models [ 86 ]."
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"The in vitro data strongly suggests that HCQ attenuates activation of the NLRP3 inflammasome and is doing this, at least in part, by blocking LMP."
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"Furthermore, Animal studies demonstrated that HCQ attenuated renal fibrosis after ischemia–reperfusion injury (IRI) by inhibiting the activation of macrophages and NLRP3 inflammasomes [28,33] ."
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"Our data had provided a new insight into the mechanism through which HCQ inhibits the activation of NLRP3 inflammasome."
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"Thus, HCQ appears to inhibit NLRP3 inflammasome activation by down-regulating CTSB and CTSL activity."
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"HCQ inhibits NLRP3 inflammasome activation in vivo and in vitro."
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"Additionally, HCQ markedly reduced macrophage and neutrophil infiltration, pro inflammatory cytokine production, and NLRP3 inflammasome activation."
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"Next we sought to determine the mechanism through which HCQ inhibits NLRP3 inflammasome activation."
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"Finally, we show that treatment of RC/RC mice with the anti-inflammatory drug HCQ, which can inhibit the NLRP3/Caspase-1 inflammasome among its effects, both protects kidney function in females and restrains cystic growth in both females and males, suggesting its potential use in the treatment of ADPKD patients.In initial studies we found that the expression of multiple cellular sensors that act upstream of Caspase-1/inflammasome activation are elevated in cystic kidneys of both human ADPKD and PKD model mice, suggesting that the inflammasome priming process has occurred."
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"Mechanistic studies showed that HCQ could inhibit the priming of the NLRP3 inflammasome by down-regulating I/R or H/R induced NF-kappaB signaling."
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"Previous studies have shown that HCQ can inhibit the NLRP3 inflammasome in immune cells (Eugenia Schroeder et al., 2017; Tang et al., 2018), and our data support these results (Supplementary Figure S7)."
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"Thus, we hypothesized that HCQ inhibits NLRP3 inflammasome activation by downregulation of CTS activity."
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