IndraLab

Statements

Hydroxychloroquine inhibits NLRP3. 15 / 15
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"Thus, we hypothesized that HCQ inhibits NLRP3 inflammasome activation by downregulation of CTS activity."
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"These data suggested that HCQ blocks NLRP3 inflammasome activation by reducing CTSB and CTSL activity."
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"In vitro studies demonstrated that HCQ attenuated activation of the NLRP3 inflammasome and blocked LMP."
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"Next we sought to determine the mechanism through which HCQ inhibits NLRP3 inflammasome activation."
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"Results : In vitro studies demonstrated that HCQ attenuated activation of the NLRP3 inflammasome and blocked LMP."
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"The in vitro data strongly suggests that HCQ attenuates activation of the NLRP3 inflammasome and is doing this, at least in part, by blocking LMP."
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"Thus, HCQ appears to inhibit NLRP3 inflammasome activation by down-regulating CTSB and CTSL activity."
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"There is evidence that hydroxychloroquine may reduce the activity of NLRP3 in inflammatory cells."
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"Mechanistic studies showed that HCQ could inhibit the priming of the NLRP3 inflammasome by down-regulating I/R or H/R induced NF-kappaB signaling."
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"To further confirm whether HCQ suppresses NLRP3 inflammasome activation through reduction of CTSB and CTSL activity, we compared the effects of HCQ and Ca074Me on H/R induced HK-2 cell injury and NLRP3 inflammasome activation."
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"Also, hydroxychloroquine significantly reduces macrophage and neutrophil infiltration, the production of inflammatory cytokines, and the activation of NLRP3 inflammasome."
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"HCQ inhibits NLRP3 inflammasome activation in vivo and in vitro."
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"Our data had provided a new insight into the mechanism through which HCQ inhibits the activation of NLRP3 inflammasome."
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"Additionally, HCQ markedly reduced macrophage and neutrophil infiltration, pro inflammatory cytokine production, and NLRP3 inflammasome activation."
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"XREF_FIG), and mRNA levels of IL-1beta, IL-6, TNF-alpha, and MCP-1 in HCQ group and HCQ+C a074Me group also showed no statistical significance, which confirmed that HCQ suppresses NLRP3 inflammasome through downregulation of CTSB and CTSL activity."
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