IndraLab

Statements

Ethanol inhibits NFKB1. 8 / 9
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"32 However, in that study, ethanol preferentially induced the inhibitory p50 and p50 homodimer, and resulted in no induction of the p65 and p50 heterodimer."
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"EtOH significantly reduced p50 (34.90 +/-23.70 vs. 197.70 +/-36.43, p < 0.05) not p52 activation."
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"In mice inflammation and pain models, NF-кB transcriptional activity and nuclear translocation of NF-кB subunit (p65 and p50) were inhibited by ethanol extracts of Gentiana macrophylla Pall and Gentia[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"On the contrary, Sklar and Nixon (2014) did not find evidence that low to moderate doses of alcohol altered P200, although ethanol significantly decreased earlier P50 and N100 gating potentials relative to placebo."
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"Stratification of impact of alcohol has shown that alcohol was able to significantly reduce p50, representing the canonical pathway, but not p52 activation, representing the non-canonical pathway of NF-ĸB signaling."
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"Previously 17β-estradiol is reported to prevent the ethanol induced neurodegeneration by targeting the NF-kB pathway and reported to reverse the oxidative damage by inhibiting the NF-KB ( Crews et al.[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"43 Studies related to alcohol intake have found that moderate doses of alcohol significantly reduce P50 sensory gating."
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"In agreement with our research, P. japonicum ethanol extract has been found to inhibit invasion by decreasing MMP-9 expression and inhibits PKC and Nf-KB signaling pathway in MCF-7 breast cancer cells [25]."
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