IndraLab

Statements


TP53 bound to TP53BP2 activates apoptotic process. 4 / 4
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"The in vivo assay demonstrated that EGFR and SOS1 promoted growth of nuclear p-AKT +, Bcl-2 + cells results in the resistance of hepatoma cells to ASPP2 and p53 complex induced apoptosis and that blocking nuclear translocation of EGFR dramatically improves and enhances the pro apoptotic function of ASPP2."

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"The association between low TP53BP2 expression and poor survival in TP53 mutated breast cancer seems counterintuitive at first, because TP53BP2 binds TP53 to induce apoptosis, and this pro apoptotic cooperation can be defective or absent when TP53 is mutated [XREF_BIBR, XREF_BIBR]."

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"Upon DNA damage or oncogenic stimuli, ASPP2 binds and activates p53, inducing apoptosis."

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"Thus, EGFR and SOS1 promoted the growth of nuclear p-AKT +, Bcl-2 + cells results in the resistance of hepatoma cells to ASPP2 and p53 complex induced apoptosis."