IndraLab

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BRCC3 activates HMGCR. 3 / 3
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"To comprehensively identify specific DUBs, we transiently expressed a series of plasmids individually encoding 44 DUBs fused with the Flag protein in 293T cells, and found that USP8, USP10, BRCC36, and JOSD1 enhanced the HMGCR protein level (Figure S3A, Supporting Information)."
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"Therefore, these findings indicate that depletion of BRCC36 promotes ferroptosis and inhibits pyroptosis primarily by regulating HMGCR expression.2.6 BRCC36 Functions as an Oncogene in Hepatic Carcinoma."
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"Moreover, BRCC36 overexpression upregulated the levels of ferroptosis suppressors HMGCR and GPX4, while those expressions decreased after the knockout of BRCC36 (Figure 5H)."
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