IndraLab

Statements

USP19 activates skeletal muscle tissue development. 3 / 3
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"Ogawa et al. report that E2 treatment of ovx mice decreased the ratio of skeletal muscle mass to body weight and increased ubiquitin-specific peptidase 19 expression, indicating that E2 inhibits myogenesis in vivo."
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"Interestingly, knockdown of USP19, which is reported to suppress myogenesis [27], did not positively affect the fusion index in this experimental setup (Fig. 1C)."
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"The ability of USP19 to modulate protein synthesis, degradation as well as myogenesis suggest that it is modulating a signaling pathway(s) that is upstream of these processes."
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