IndraLab

Statements

MIR21 inhibits YOD1. 8 / 8
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"These findings indicate that miR-21 inhibited YOD1 at the translational level, but did not induce degradation of YOD1 mRNA."
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"zTo confirm that the YOD1 suppression by miR-21 leads to the degradation of desmin during CVB3 infection, we utilized small interference RNA (siRNA) to knockdown endogenous YOD1, which mimicked the effect of miR-21 on YOD1 expression."
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"To further confirm that YOD1 inhibition and desmin downregulation is mediated by miR-21, we transfected cells with miR-362 as an additional non specific control, which showed no effect on the expression levels of gamma-catenin, desmin, YOD1 and ubiquitinated desmin."
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"Our results indicated that miR-21 negatively regulates YOD1 by binding to two sites in its 3′-UTR region."
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"Accordingly, miR-21 knockdown increased YOD1 and decreased α-SMA in CAFs ( Fig. 5 E, H)."
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"Suppression of YOD1 by miR-21 promoted desmin degradation and desmosome disorganization."
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"Similar reduction of YOD1 by miR-21 was observed in CVB3 infected samples (XREF_FIG)."
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"These findings indicate that miR-21 inhibited YOD1 at the translational level, but did not induce degradation of YOD1 mRNA."
37568787