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SIRT1 inhibits OTUD3. 3 / 3
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"Further, upon SeV infection, the Silent information regulator factor 2-related enzyme 1 (Sirt-1) deacetylates (K129) and inactivates OTUD3 and thereby prevents the K63-deubiquitinylation of MAVS [ 19 [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"In response to a viral infection, acetylated Lys129 is deacylated and eliminated by SIRT1, which rapidly inactivates OTUD3, inducing innate antiviral immunity by upregulating the viral activation of MAVS and inducing type 1 IFN (222)."
35795579
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"In response to a viral infection, acetylated Lys129 is deacylated and eliminated by SIRT1, which rapidly inactivates OTUD3, inducing innate antiviral immunity by upregulating the viral activation of MAVS and inducing type 1 IFN ( xref )."
35795579