IndraLab

Statements

OTUB2 activates CD274. 4 / 4
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"To further explore the cellular location at which OTUB2 prevents the proteasomal degradation of PD-L1, we performed immunofluorescence (IF) following Duolink in situ PLAs using antibodies targeting different organelles to confirm the subcellular location of the OTUB2–PD-L1 interaction."
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"In this study, we demonstrate OTUB2-mediated PD-L1 regulation as a common feature in various human and mouse cancers, particularly in NSCLC."
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"Given the important role of OTUB2-mediated PD-L1 stability in suppression of tumor growth, we reasoned that targeting OTUB2 could be beneficial in the treatment of cancer."
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"To determine whether OTUB2-mediated PD-L1 stabilization is regulated by deubiquitination, we asked whether OTUB2 deubiquitinates PD-L1 to increase protein stability."
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