IndraLab

Statements

Tetrodotoxin inhibits SCN4A. 6 / 6
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"Tetrodotoxin significantly slowed the HCN2 and SkM1 -injected preparations, bringing their beating rates into the same range as the HCN2 -injected preparations."
23395072
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"Classically, nanomolar concentration of tetrodotoxin (TTX) blocks SkM1 channels whereas inhibition of SkM2 channels requires TTX concentration in the micromolar range."
9733912
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"With isoproterenol 0.1 muM superfusion maintained, we added tetrodotoxin 0.1 muM, which selectively blocks SkM1 current."
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"With isoproterenol 0.1 muM superfusion maintained, we added tetrodotoxin 0.1 muM, which selectively blocks SkM1 current (7)."
23395072
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"SkM1 current should be reduced by 100 nM TTX, while that of native SCN5A channels should be minimally affected."
19103989
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"Classically, nanomolar concentration of tetrodotoxin (TTX) blocks SkM1 channels whereas inhibition of SkM2 channels requires TTX concentration in the micromolar range."
9733912