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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

OLR1 activates TNFAIP3. 2 / 2

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"Overexpression of LOX1 activates an NF-kappaB-dependent antiapoptotic pathway (BCL2, BCL2A1, and TNFAIP3)."

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"Overexpression of LOX1 activated an NF-kappaB-dependent anti-apoptosis pathway (BCL2, BCL2A1, and TNFAIP3) as well as lipogenesis in MCF10A normal mammary epithelial cells and HCC1143 breast cancer cells, suggesting that LOX-1 acts as an oncogene promoting tumorigenesis."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...