IndraLab

Statements

(R)-lipoic acid inhibits RELA. 5 / 5
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reach
"Heat killed LA failed to attenuate PAF induced increase in nuclear p65, whereas, similar to live LA, its CS (diluted 1:10 in DMEM and F12) was equally effective in attenuating the PAF effects on nuclear p65 (XREF_FIG)."
24130731
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"As shown in XREF_FIG, the two species, L. acidophilus (LA) and L. rhamnosus (LR) significantly attenuated the PAF induced increase in nuclear p65, whereas the other two species were ineffective."
24130731
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"The results showed that inhibitor of phosphatidylinositol 3-kinase prevented LA mediated suppression of LPS induction of RelA and expression of iNOS."
23892131
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"LA suppressed IL-33-induced activation of NFkappaB p65, JNK, ERK, and TAK1, without altering p38 phosphorylation (XREF_FIG)."
27559047
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"Interestingly, our current studies also showed that heat killed LA failed to attenuate PAF induced increase in nuclear p65 and importantly, bacteria-free CS of LA was as effective as live LA in attenuating the PAF effects on nuclear p65, indicating that LA effects on PAF induced NF-kappaB activation are mediated by secreted soluble factor (s) in the CS."
24130731