IndraLab

Statements

(R)-lipoic acid inhibits RELA. 6 / 6
| 6
reach
"As shown in XREF_FIG, the two species, L. acidophilus (LA) and L. rhamnosus (LR) significantly attenuated the PAF induced increase in nuclear p65, whereas the other two species were ineffective."
24130731
reach
"Heat killed LA failed to attenuate PAF induced increase in nuclear p65, whereas, similar to live LA, its CS (diluted 1:10 in DMEM and F12) was equally effective in attenuating the PAF effects on nuclear p65 (XREF_FIG)."
24130731
reach
"LA suppressed IL-33-induced activation of NFkappaB p65, JNK, ERK, and TAK1, without altering p38 phosphorylation (XREF_FIG)."
27559047
reach
"When the higher LPS concentration of 10 µg/mL was used for stimulation, both VA and LA were found to negatively regulate nuclear p65 and have an inhibitory effect on the NF-ĸB activation, as nuclear p65 was reduced upon treatment with VA and LA at both concentrations tested (Figure 6C3)."
38891984
reach
"The results showed that inhibitor of phosphatidylinositol 3-kinase prevented LA mediated suppression of LPS induction of RelA and expression of iNOS."
23892131
reach
"Interestingly, our current studies also showed that heat killed LA failed to attenuate PAF induced increase in nuclear p65 and importantly, bacteria-free CS of LA was as effective as live LA in attenuating the PAF effects on nuclear p65, indicating that LA effects on PAF induced NF-kappaB activation are mediated by secreted soluble factor (s) in the CS."
24130731