IndraLab

Statements

P5091 inhibits Neoplasms. 9 / 9
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"In the mouse xenograft model studies, P5091 was well tolerated and inhibited tumor growth associated with downregulated Wnt signaling."
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"All of these results proved that both P5091 and anti-PD-1 treatment enhanced tumor proliferation inhibition and apoptosis in vivo."
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"In a transgenic mouse model of PDAC, named KPC, P5091 effectively blocks tumor progression."
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"P5091 has been shown to inhibit tumor growth by inhibiting USP7 and USP47 and is well tolerated in animals [107] ."
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"In addition, P5091 inhibits tumor growth and synergizes with other chemotherapeutic agents such as lenalidomide, HDAC inhibitor or dexamethasone to induce synergistic anti-multiple myeloma effect [32, 33]."
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"P5091 was reported to be well tolerated by animals and to inhibit tumor growth ( Chauhan et al., 2012 )."
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"In multiple myeloma cell lines, P5091 stabilized p53 and inhibited tumor growth, and prolonged survival as a single agent in xenograft studies."
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"P5091 treatment inhibited melanoma tumor growth Figure 7 F)."
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"In the HCT116 xenograft mouse model, P5091 also inhibited tumor growth in vivo, which was consistently associated with decreased expression of β-catenin and Wnt target genes."
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