IndraLab

Statements

CYLD activates cell migration. 4 / 4
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"Catalytic domain mutation in CYLD inactivates its enzyme function by structural perturbation and induces cell migration and proliferation."
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"In contrast to the proliferation related activity, CYLD knockdown significantly decreased the cell migration of all the melanoma cell lines (n = 7, p < 0.05), and we demonstrated that the mechanism regulating melanoma cell migration was activation of RAC1 through the action of CYLD."
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"CYLD has also been shown to stimulate cell migration and thereby contribute to normal physiological processes."
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"In addition, CYLD m induced an increased rate of cell migration as assessed by a scratch wounding assay, while CYLD WT markedly slowed cell migration (XREF_FIG)."
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