IndraLab

Statements


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reach
"Together, these data indicate that NO activates USP9X by S nitrosylation, which deubiquitinates and stabilizes MIB1, and this is followed by the activation of NOTCH1 signaling to prevent calcification."

reach
"Recent initial applications of PTM analysis to CAVD revealed that nitric oxide modulates S-nitrosylation of the deubiquitinase USP9X and controls anti-calcific NOTCH in cultured VICs."

reach
"NO activates USP9X to deubiquitinate MIB1."

eidos
"Together , these data indicate that NO activates USP9X by S-nitrosylation , which deubiquitinates and stabilizes MIB1 , and this is followed by the activation of NOTCH1 signaling to prevent calcification ."