IndraLab

Statements

USP10 activates NOTCH1. 4 / 4
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"Ubiquitin-specific peptidase 10 (USP10), a deubiquitinating enzyme, interacts with NICD1 to slow the ubiquitin-dependent turnover of the activated Notch-1 receptor, thereby eliminating the ubiquitination of NICD1 and stimulating Notch signaling in ECs (142)."
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"In DiaCM, USP10 has been shown that it can activate Notch1 to exert protective effect on MI in T2DM mice [117]."
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"In conclusion, our results revealed a novel mechanism by which USP10-mediated activation of Notch1 plays a protective role against MI injury in T2DM mice."
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"USP10, a deubiquitinating enzyme, modulates the Notch signaling pathway by targeting NICD1, the receptor of Notch1 (139)."
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