IndraLab

Statements

CACNA1A inhibits CAV1. 6 / 6
| 6
sparser
"Mutations within the CaN binding motif, A1929P, or H1926A/H1927A, accelerate the rate of Cav1.2 voltage-dependent inactivation."
22511998
sparser
"Voltage-dependent inactivation of Cav1.2 develops during the plateau phase of the cardiac action potential (AP) and enables timed repolarization and tuned calcium entry."
28766141
sparser
"The underlying mutations reduce voltage-dependent inactivation of Cav1.2. xref In the heart depolarizing Ca 2+ current increases, causing delayed cardiomyocyte repolarization, prolongation of the QT-interval and enhances the risk for lethal ventricular arrhythmias."
26039257
sparser
"Taken together, we identified a dominant role of segment IS4 in voltage-dependent inactivation of Cav1.2."
28766141
sparser
"Our results reveal a novel critical extracellular determinant of current density for all Cav family members and of voltage-dependent inactivation of Cav1.3 and Cav2.1 channels."
30054272
sparser
"In the present study, we investigate the role of S4 charges in voltage-dependent inactivation of Cav1.2."
28766141