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COPS6 inhibits BTRC. 5 / 5
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"To test whether CSN6 increased the ubiquitinated degradation of β-TrCP in PASMCs stimulated with PDGF, cells were pre-treated with proteasome inhibitor MG-132 (10 μM) for 12 h, and then stimulated wit[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Furthermore, CSN6 has been found to decrease β-TrCP by promoting its autocatalytic degradation, thereby stabilizing SCF ubiquitin ligase substrate in colorectal cancer cells [22] ."
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"However, it is unclear whether up-regulation of CSN6 decreases β-TrCP by increasing its ubiquitinated degradation, thereby increasing the lifetime of Cdc25A in PDGF-stimulated PASMCs."
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"This indicated that up-regulation of CSN6 by PDGFR / PI3K / Akt signaling promotes beta-TrCP degradation , which , in turn , stabilizes the cell cycle protein Cdc25A and results in PASMC proliferation ."
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"Epidermal-growth-factor (EGF)-induced extracellular signal-regulated kinase 2 (ERK2) activation phosphorylates CSN6 at S148, leading to β-catenin stabilization through blocking β-TrCP and colorectal cancer development [123]."
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