IndraLab

Statements

UCHL1 increases the amount of HIF1A. 3 / 3
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"Genetic deletion or chemical inhibition of UCHL1 reduces HIF1alpha levels in hepatic stellate cells."
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"In addition to such a molecular mechanism, we recently revealed the possibility that UCHL1 increases the expression levels of HIF-1alpha by upregulating the efficiency of the transcriptional initiation of the HIF-1alpha gene (data not shown)."
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"Western blotting consistently showed that the UCHL1 dependent increase in HIF-1alpha protein levels was only observed in the presence of VHL (XREF_FIG)."
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