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Bufadienolide inhibits JAK1. 2 / 2
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"The exact cellular target of the cardenolides is associated with Ndfip1/2-(NEDD4)-JAK1 and likely also a membrane protein, but remains to be identified.Strikingly, whereas the natural cardenolides and[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Strikingly , whereas the natural cardenolides and bufalin ( a bufadienolide ) could induce significant JAK1 diminishment , the two innovative Na + / K + - ATPase effectors istaroxin ( an inhibitor ) and rostafuroxin ( a modulator ) [ 21 ] , [ 22 ] examined herein ( Figure 4D ) could not ."
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