IndraLab

Statements


USP26 activates BRCA1. 3 / 3
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"Loss of USP26 or USP37 impairs HR by counteracting RAP80 dependent sequestration of BRCA1."

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"On the other hand, we also found that USP26 and USP37 promote the efficient association of BRCA1 with PALB2."

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"Together, these results suggest that USP26 and USP37 promote the BRCA1 dependent loading of PALB2 and RAD51 by counteracting the repressive impact of RAP80 dependent BRCA1 sequestration and RAP80 dependent inhibition of end-resection during HR."