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Imipramine inhibits KCNH2. 6 / 13
4 2 1 | 6
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"HERG tail currents (IHERG) following test pulses to +20 mV were inhibited by imipramine with an IC50 of 3.4 +/-0.4 microM (mean +/-s.e.mean) and a Hill coefficient of 1.17 +/-0.03 (n = 5)."
10510461
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"Once maximal channel activation was achieved after 320 ms (as demonstrated by maximal tail currents), further prolongation of depolarization did not increase imipramine mediated HERG channel inhibition."
10510461
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"Imipramine blocks several cardiac and neuronal voltage gated and Ca 2+ -activated K + channels as well as EGL-2 channels, hERG channels, neuronal and cardiac Na + channels, and Ca 2+ channels."
15365094
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"Amitriptyline, quinidine, compound A, fluoxetine and imipramine inhibited hERG with IC 50 values (all paired values denote constantly cultured and frozen, respectively) of 4.8 +/- 0.4 and 5.1 +/- 0.4,[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
21996251
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"Previously, imipramine has been reported to inhibit I HERG recorded in experiments using a mammalian expression system with an IC 50 of 3.4 muM XREF_BIBR whilst an IC 50 of 10muM was reported for amitriptyline XREF_BIBR."
17560554
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"For example, amitriptyline, imipramine, and doxepin block the HERG channel with the IC 50 s of 10 muM, 3.4 muM, and 6.5 muM, respectively (Cavalli et al., 2002; Duncan et al., 2007)."
18191158