IndraLab

Statements

Imipramine inhibits KCNH2. 13 / 13
4 2 | 7
reach
"Once maximal channel activation was achieved after 320 ms (as demonstrated by maximal tail currents), further prolongation of depolarization did not increase imipramine mediated HERG channel inhibition."
10510461
tas
No evidence text available
15911273
tas
No evidence text available
19534531
reach
"Amitriptyline, quinidine, compound A, fluoxetine and imipramine inhibited hERG with IC 50 values (all paired values denote constantly cultured and frozen, respectively) of 4.8 +/- 0.4 and 5.1 +/- 0.4,[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
21996251
reach
"HERG tail currents (IHERG) following test pulses to +20 mV were inhibited by imipramine with an IC50 of 3.4 +/-0.4 microM (mean +/-s.e.mean) and a Hill coefficient of 1.17 +/-0.03 (n = 5)."
10510461
reach
"Previously, imipramine has been reported to inhibit I HERG recorded in experiments using a mammalian expression system with an IC 50 of 3.4 muM XREF_BIBR whilst an IC 50 of 10muM was reported for amitriptyline XREF_BIBR."
17560554
ctd
No evidence text available
15272206
ctd
No evidence text available
24052561
reach
"Amitriptyline, quinidine, compound A, fluoxetine and imipramine inhibited hERG with IC (50) s (paired values denote constantly cultured and frozen, respectively) of 4.8 +/-0.4 and 5.1 +/-0.4, 1.4 +/-0.1 and 1.1 +/-0.1, 24.4 +/-2.4 and 21.9 +/-1.8, 2.1 +/-0.4 and 2.1 +/-0.1, 5.2 +/-0.4 and 4.0 +/-0.2 muM."
21996251
reach
"For example, amitriptyline, imipramine, and doxepin block the HERG channel with the IC 50 s of 10 muM, 3.4 muM, and 6.5 muM, respectively (Cavalli et al., 2002; Duncan et al., 2007)."
18191158
tas
No evidence text available
21185626
reach
"Imipramine blocks several cardiac and neuronal voltage gated and Ca 2+ -activated K + channels as well as EGL-2 channels, hERG channels, neuronal and cardiac Na + channels, and Ca 2+ channels."
15365094
tas
No evidence text available
18243713